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Upon application, it increases cutaneous blood flow.
September 13, 2024
By: Christine Esposito
US Patent No. 12,083,204 B2 (Jacob Waugh, Jonah Shacknai); L’Oréal Paris has been awarded a US patent for a topical composition for treating aging-related skin conditions. It is comprised of adenosine (0.01 – 0.5 wt %), arginine (0.1 – 1.0 wt %), carnosine (0.05 – 0.2 wt %), niacinamide (0.5 – 6 wt %) and a magnesium ion source present from approximately 0.1 – 1.0 wt %.
Upon application of the composition to the skin, a nitric oxide is produced or generated and increases cutaneous blood flow in the skin region compared to cutaneous blood flow in a similar skin region not treated with the composition, as measured by doppler ultrasound.
The composition is suitable for at least daily topical application to skin for a period of at least 32 days, according to the patent literature.
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